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Science. 1996 Aug 16;273(5277):923.
A receptor in pituitary and hypothalamus that functions in growth hormone release.
Howard AD,
Feighner SD,
Cully DF,
Arena JP,
Liberator PA,
Rosenblum CI,
Hamelin M,
Hreniuk DL,
Palyha OC,
Anderson J,
Paress PS,
Diaz C,
Chou M,
Liu KK,
McKee KK,
Pong SS,
Chaung LY,
Elbrecht A,
Dashkevicz M,
Heavens R,
Rigby M,
Sirinathsinghji DJ,
Dean DC,
Melillo DG,
Patchett AA,
Nargund R,
Griffin PR,
DeMartino JA,
Gupta SK,
Schaeffer JM,
Smith RG,
Van der Ploeg LH.
Merck Research Laboratories, Rahway, NJ 07065, USA.
Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.
PMID: 8688086 [PubMed - indexed for MEDLINE]
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