-
- Comment in:
-
Science. 1996 Aug 16;273(5277):923.
A receptor in pituitary and hypothalamus that functions in growth hormone release.
Howard AD,
Feighner SD,
Cully DF,
Arena JP,
Liberator PA,
Rosenblum CI,
Hamelin M,
Hreniuk DL,
Palyha OC,
Anderson J,
Paress PS,
Diaz C,
Chou M,
Liu KK,
McKee KK,
Pong SS,
Chaung LY,
Elbrecht A,
Dashkevicz M,
Heavens R,
Rigby M,
Sirinathsinghji DJ,
Dean DC,
Melillo DG,
Patchett AA,
Nargund R,
Griffin PR,
DeMartino JA,
Gupta SK,
Schaeffer JM,
Smith RG,
Van der Ploeg LH.
Merck Research Laboratories, Rahway, NJ 07065, USA.
Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.
PMID: 8688086 [PubMed - indexed for MEDLINE]
-
Cited by 35 PubMed Central articles
-
Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance.
Mager U, Degenhardt T, Pulkkinen L, Kolehmainen M, Tolppanen AM, Lindström J, Eriksson JG, Carlberg C, Tuomilehto J, Uusitupa M, et al.
PLoS One. 2008 Aug 13; 3(8):e2941. Epub 2008 Aug 13.
[PLoS One. 2008]
-
Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats.
Strassburg S, Anker SD, Castaneda TR, Burget L, Perez-Tilve D, Pfluger PT, Nogueiras R, Halem H, Dong JZ, Culler MD, et al.
Am J Physiol Endocrinol Metab. 2008 Jul; 295(1):E78-84. Epub 2008 May 6.
[Am J Physiol Endocrinol Metab. 2008]
-
Gastric motor effects of ghrelin and growth hormone releasing peptide 6 in diabetic mice with gastroparesis.
Qiu WC, Wang ZG, Wang WG, Yan J, Zheng Q.
World J Gastroenterol. 2008 Mar 7; 14(9):1419-24.
[World J Gastroenterol. 2008]
- » See all...