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Eur Heart J. 1995 Dec;16 Suppl O:15-7.

Genetics of coxsackievirus B3 cardiovirulence.

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  • 1Department of Pathology, University of Nebraska Medical Center, Omaha 68198, USA.


The human enteroviruses, especially the coxsackie B viruses, have been established as aetiologic agents of human inflammatory heart disease, a condition which may lead to dilated cardiomyopathy and heart failure. It is clear from murine models of coxsackievirus B3-induced inflammatory heart disease that not all strains of the virus are cardiovirulent (able to cause disease). Here, we present preliminary data mapping the site in a coxsackievirus B3 genome which determines a cardiovirulent phenotype.

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