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    Biochem Biophys Res Commun. 1996 Jun 14;223(2):304-10.

    cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b).

    Hino J, Takao M, Takeshita N, Konno Y, Nishizawa T, Matsuo H, Kangawa K.

    Source

    National Cardiovascular Center Research Institute, Fujishirodai, Suita, Osaka, Japan.

    Abstract

    BMP-3b (also termed GDF-10) is a novel BMP-3 related protein recently discovered in rat femur tissue by molecular cloning. In this paper, we have isolated cDNA and the gene for human BMP-3b and determined their structure. Cloned human BMP-3b cDNA with a size of 2632 base pairs encodes a 478 amino acid precursor protein sharing 83% identity with rat BMP-3b. The human BMP-3b gene is composed of 3 exons and spans approximately 13 kilobases of DNA. The 5' flanking region carries no typical TATA box but G+C rich sequences. Southern blot analysis revealed that the BMP-3b gene is situated in a single locus of chromosome 10. By Northern analysis, human BMP-3b transcripts were detected primarily in femur, brain, lung, skeletal muscle, pancreas and testis.

    PMID:
    8670277
    [PubMed - indexed for MEDLINE]

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