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Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor.
INSERM U311, Etablissement de Transfusion Sanguine de Strasbourg, France.
We have cloned and sequenced a 3055-bp human placenta cDNA encoding a P2 purinoceptor. An identical receptor has also been found in human saphenous vein endothelial cells. Comparison of the deduced amino acid (aa) sequence to those of previously described P2Y1 purinoceptors revealed greater than 95% aa identity with the rat and mouse counterparts, and 83% with the chick P2Y1 purinoceptor. Northern blot experiments revealed two mRNAs of 7.5 and 4.6 kb whose expression varies according to the tissue examined.
PMID: 8666290 [PubMed - indexed for MEDLINE]
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Cited by 5 PubMed Central articles
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[32P]2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors.
Houston D, Ohno M, Nicholas RA, Jacobson KA, Harden TK.
Br J Pharmacol. 2006 Mar; 147(5):459-67.
[Br J Pharmacol. 2006]
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Potent P2Y6 receptor mediated contractions in human cerebral arteries.
Malmsjö M, Hou M, Pendergast W, Erlinge D, Edvinsson L.
BMC Pharmacol. 2003 May 9; 3:4. Epub 2003 May 9.
[BMC Pharmacol. 2003]
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Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs.
Foster CJ, Prosser DM, Agans JM, Zhai Y, Smith MD, Lachowicz JE, Zhang FL, Gustafson E, Monsma FJ Jr, Wiekowski MT, et al.
J Clin Invest. 2001 Jun; 107(12):1591-8.
[J Clin Invest. 2001]
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