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    Nature. 1996 Jun 20;381(6584):667-73.

    HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.

    Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup RA, Moore JP, Paxton WA.

    Source

    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York 10016, USA.

    Abstract

    The beta-chemokines MIP-1alpha, MIP-1beta and RANTES inhibit infection of CD4+ T cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell-cell membrane fusion. CD4+ T cells from some HIV-1-exposed uninfected individuals cannot fuse with NSI HIV-1 strains and secrete high levels of beta-chemokines. Expression of the beta-chemokine receptor CC-CKR-5 in CD4+, non-permissive human and non-human cells renders them susceptible to infection by NSI strains, and allows env-mediated membrane fusion. CC-CKR-5 is a second receptor for NSI primary viruses.

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    PMID:
    8649512
    [PubMed - indexed for MEDLINE]

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