Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nature. 1996 Jun 20;381(6584):667-73.

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.

Author information

  • 1The Aaron Diamond AIDS Research Center, The Rockefeller University, New York 10016, USA.

Abstract

The beta-chemokines MIP-1alpha, MIP-1beta and RANTES inhibit infection of CD4+ T cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell-cell membrane fusion. CD4+ T cells from some HIV-1-exposed uninfected individuals cannot fuse with NSI HIV-1 strains and secrete high levels of beta-chemokines. Expression of the beta-chemokine receptor CC-CKR-5 in CD4+, non-permissive human and non-human cells renders them susceptible to infection by NSI strains, and allows env-mediated membrane fusion. CC-CKR-5 is a second receptor for NSI primary viruses.

Comment in

  • Hot fusion of HIV. [Nature. 1996]
PMID:
8649512
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk