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Nature. 1996 Jun 20;381(6584):661-6.

Identification of a major co-receptor for primary isolates of HIV-1.

Author information

  • 1Skirball Institute for BioMolecular Medicine, New York University Medical Center, 10016, USA.

Abstract

Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta.

Comment in

  • Hot fusion of HIV. [Nature. 1996]
PMID:
8649511
[PubMed - indexed for MEDLINE]
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