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    FEBS Lett. 1996 May 20;386(2-3):189-93.

    Human high affinity, Na(+)-dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): gene structure and localization to chromosome 5p11-p12.

    Stoffel W, Sasse J, Düker M, Müller R, Hofmann K, Fink T, Lichter P.

    Institut für Biochemie, Universität zu Köln, Germany. akc03@rs1.rrz.uni-kocln.de

    The gene of the human L-glutamate transporter hGLAST-1 (EAAT-1) has been isolated and characterized. The 1626 bp cDNA open reading frame (542 aa) is distributed over ten exons and at least 85 kb on chromosome 5p11-p12. The gene is unrelated to any other previously described neurotransmitter transporter gene family, but its exon/intron structure corresponds largely to that of the Na(+)-dependent neutral amino acid transporter ASCT-1. GLAST-1, ASCT-1 and the glutamate transporters GLT-1 and EAAC-1 have strongly similar amino acid sequences. The L-glutamate transporter gene structures might help to understand the correlation of L-glutamate reuptake in neurodegenerative disorders.

    PMID: 8647279 [PubMed - indexed for MEDLINE]

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