Send to:

Choose Destination
See comment in PubMed Commons below
Mech Dev. 1995 Nov;53(3):383-92.

Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick.

Author information

  • 1Department of Cell Biology, Vanderbilt University Medical School, Nashville, TN 37232, USA.


Expression of Fgf-8, Bmp-4, Bmp-7, and shh in the branchial arches of the chick embryo is examined by in situ hybridization. Fgf-8 expression is initially broad and diffuse, becoming more tightly restricted, particularly in the epithelium of the posterior ectodermal margin (PEM) of the 2nd branchial arch. Bmp-7 transcripts, first seen at stage 12 in discrete regions corresponding to the developing branchial clefts, are later detected in both clefts and arches, including the PEM of the 2nd arch while Bmp-4 transcripts are detected at stage 18 in the distal tips of the arches. Shh expression remains localized, overlapping with both Bmp-7 and Fgf-8 in the PEM of the 2nd arch at stages 16 and 18. Based on these data, a model is proposed for the role of these signalling molecules in branchial arch development.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk