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    Biochem Biophys Res Commun. 1996 Feb 27;219(3):789-94.

    Genomic organization of the human bone morphogenetic protein-4 gene: molecular basis for multiple transcripts.

    van den Wijngaard A, van Kraay M, van Zoelen EJ, Olijve W, Boersma CJ.

    Laboratory for Applied Biology, University of Nijmegen, The Netherlands.

    The structure of the human bone morphogenetic protein-4 (BMP-4) gene has been characterized from a genomic cosmid clone of about 38 kb. The transcriptional unit of the human BMP-4 gene is encoded by 5 exons and spans approximately 7 kb. The exon-intron organization of the human BMP-4 gene is similar to that of the mouse gene, with notable sequence differences in the 5' non-coding exons. The human BMP-4 gene has at least two functional promoters, which are used in a cell type specific manner. This observation is of fundamental relevance for understanding the specific role of BMP-4 in skeletal development and bone remodeling.

    PMID: 8645259 [PubMed - indexed for MEDLINE]

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