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1: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3937-41.Click here to read Links

A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene.

Stoffel M, Le Beau MM, Espinosa R 3rd, Bohlander SF, Le Paslier D, Cohen D, Xiang KS, Cox NJ, Fajans SS, Bell GI.

Howard Hughes Medical Institute, University of Chicago, IL 60637, USA.

We have generated a physical map of human chromosome bands 20q11.2-20q13.1, a region containing a gene involved in the development of one form of early-onset, non-insulin-dependent diabetes mellitus, MODY1, as well as a putative myeloid tumor suppressor gene. The yeast artificial chromosome contig consists of 71 clones onto which 71 markers, including 20 genes, 5 expressed sequence tags, 32 simple tandem repeat DNA polymorphisms, and 14 sequence-tagged sites have been ordered. This region spans about 18 Mb, which represents about 40% of the physical length of 20q. Using this physical map, we have refined the location of MODY1 to a 13-centimorgan interval (approximately equal to 7 Mb) between D20S169 and D20S176. The myeloid tumor suppressor gene was localized to an 18-centimorgan interval (approximately equal to 13 Mb) between RPN2 and D20S17. This physical map will facilitate the isolation of MODY1 and the myeloid tumor suppressor gene.

PMID: 8632993 [PubMed - indexed for MEDLINE]

PMCID: PMC39463