K1 and K3 capsular antigens of Klebsiella induce tumor necrosis factor activities

Y M Choy; S F Tsang; S K Kong; K N Leung; H Parolis; C Y Lee; K P Fung

doi:10.1016/0024-3205(95)02361-5

K1 and K3 capsular antigens of Klebsiella induce tumor necrosis factor activities

Life Sci. 1996;58(9):PL153-8. doi: 10.1016/0024-3205(95)02361-5.

Authors

Y M Choy¹, S F Tsang, S K Kong, K N Leung, H Parolis, C Y Lee, K P Fung

Affiliation

¹ Department of Biochemistry, The Chinese University of Hong Kong, Shatin, Hong Kong.

PMID: 8632718
DOI: 10.1016/0024-3205(95)02361-5

Abstract

Capsular polysaccharide antigens isolated from Klebsiella pneumoniae sero-type 1 (K1) and sero-type 3 (K3) could induce tumor necrosis factor-alpha in ICR mice. K1 and K3 capsular antigens were found to be non-toxic by brine shrimp bioassay. When injected into Ehrlich ascites tumor-bearing mice, both K1 and K3 capsular antigens exhibited significant suppression in the growth of tumor cells. The significance of these observations is discussed.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, Bacterial / pharmacology*
Artemia
Bacterial Capsules
Berberine / toxicity
Carcinoma, Ehrlich Tumor
Cell Division / drug effects
Hippurates / toxicity
Klebsiella pneumoniae / immunology*
Mice
Mice, Inbred ICR
Polysaccharides, Bacterial / isolation & purification
Polysaccharides, Bacterial / pharmacology*
Polysaccharides, Bacterial / toxicity
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha / biosynthesis*

Substances

Antigens, Bacterial
Hippurates
Polysaccharides, Bacterial
Tumor Necrosis Factor-alpha
capsular polysaccharide K1
capsular polysaccharide K3
Berberine
hippuric acid