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    Biochem Biophys Res Commun. 1996 Apr 25;221(3):768-72.

    Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter.

    Sakaue M, Kitazawa S, Nishida K, Kitazawa R, Maeda S.

    Second Department of Pathology, Kobe University School of Medicine, Japan.

    The bone morphogenic proteins (BMPs) constitute a novel subfamily of the transforming growth factor type beta (TGF-beta) supergene family and play a critical role in modulating mesenchymal differentiation and inducing the processes of cartilage and bone formation. In this study we isolated the 5'-flanking region of the human BMP-5 gene. Nucleotide sequencing, primer extension, DNase I foot printing and functional analysis by transient expression showed that the cloned 1.5 kb promoter region contains two transcription start sites, a canonical TATA box (-17 approximately -12) and a number of consensus recognition sequences including GATA-1 (-582 approximately -576) and engrailed (-549 approximately -541).

    PMID: 8630036 [PubMed - indexed for MEDLINE]

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