Biochem Biophys Res Commun. 1996 Apr 25;221(3):602-8.

Suppression of translation frameshift by upstream termination codon.

Source

Banyu Tsukuba Research Institute, Merck Research Laboratories, Ibarakgi, Japan. ayhonda@lab.nig.ac.jp.

Abstract

Retroviruses employ translation frameshift for gene expression. Translation frameshift takes place at the slippery heptanucleotide sequence on mRNA. A downstream stem-loop structure (and a pseudoknot formed by the stem-loop) enhances the level of ribosomal frameshifting. Here, we describe that an upstream termination codon suppresses the ribosomal frameshifting, leading to reduction in the expression of downstream genes.

PMID:: 8630007; [PubMed - indexed for MEDLINE]

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