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J Virol. 1996 May;70(5):3325-9.

Characterization of long-term cultures of hepatitis C virus.

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  • 1Department of Bacteriology, Faculty of Medicine, University of Tokyo, Japan.

Abstract

The human T- and B-cell lines HPBMa10-2 and Daudi produced infectious hepatitis C virus (HCV) for more than 1 year after infection. The infectivity titer of the cell culture-grown HCV and its genome titer were comparable. The virion density in sucrose was around 1.12 g/ml. Among the 13 variants detected in the inoculum, 7 were adsorbed by the cells and one particular HCV sequence which was present in minor quantities in the inoculum persisted.

PMID:
8627819
PMCID:
PMC190202
[PubMed - indexed for MEDLINE]
Free PMC Article
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