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J Biol Chem. 1996 Mar 15;271(11):6241-4.

A nascent secretory protein may traverse the ribosome/endoplasmic reticulum translocase complex as an extended chain.

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  • 1Department of Biochemistry, Stockholm University, Sweden.


We have measured the minimum number of residues in a translocating polypeptide required to bridge the distance between the P-site in endoplasmic reticulum-bound ribosomes and the lumenally disposed active site of the oligosaccharyl transferase. The results suggest that a nascent chain may traverse the ribosome/translocase complex in a largely extended conformation, and that hydrophobic stop-transfer segments have a more compact, possibly alpha-helical conformation in the translocase.

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