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Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3536-41.

cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes.

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  • 1Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA.

Erratum in

  • Proc Natl Acad Sci U S A 1996 Jul 23;93(15):8154.


Stimulation of the cAMP-dependent signaling pathway exerts an inhibitory effect on the proliferation and effector functions of T cells. The ability of T cells to form high intracellular levels of cAMP is acquired during development in the human thymus and is retained by the majority of mature peripheral T lymphocytes. Here we show that elevated cAMP levels in T cells correlate with the expression of the potent transcriptional repressor ICER (inducible cAMP early repressor) previously described in the hypothalamic-pituitary-gonadal axis. Further, in transcriptional assays in vivo, ICER inhibits calcineurin-mediated expression of the interleukin 2 promoter as well as Tax-mediated transactivation of the human T-lymphotropic virus type I (HTLV-I) promoter. Thus, the induction of ICER in T cells may play an important role in the cAMP-induced quiescence and the persistent latency of HTLV-I.

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