J Pediatr. 1996 Apr;128(4):573-6.

Comparison of chloral hydrate and midazolam for sedation of neonates for neuroimaging studies.

McCarver-May DG, Kang J, Aouthmany M, Elton R, Mowery JL, Slovis TL, Kauffman R.

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Department of Pediatrics, Children's Hospital of Michigan, Detroit, USA.

Abstract

In a crossover study of seven term neonates who had neuroimaging studies, chloral hydrate (75 mg/kg administered orally) was more efficacious (p<0.05) but similar with regard to toxic effects than midazolam (0.2 mg/kg administered intravenously). Thus newer drugs are not necessarily better, and monitoring is essential even after a single oral sedative dose.

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J Pediatr. 1996 Dec;129(6):944-5.

PMID:: 8618198; [PubMed - indexed for MEDLINE]

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