Send to:

Choose Destination
See comment in PubMed Commons below
J Invest Dermatol. 1996 Apr;106(4):785-9.

Histamine in human epidermal cells is induced by ultraviolet light injury.

Author information

  • 1Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.


Human epidermal cell cultures were examined to determine whether they were capable of histamine release. Results of these studies indicated that keratinocytes contain and release significant amounts of histamine. In the skin of some individuals, histamine content was induced after ultraviolet B light injury, and 40% of subjects demonstrated high basal histamine levels. Mass spectrometric analysis of cell supernatants showed that the histamine was released into the extracellular environment. Such release may contribute to common itching or intensify the inflammatory response in vivo.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk