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BMJ. 1996 Apr 27;312(7038):1061-5.

C reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study.

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  • 1Division of Biochemical Medicine, St George's Medical School, London.

Abstract

OBJECTIVE:

To test the hypothesis that minor chronic insults such as smoking, chronic bronchitis, and two persistent bacterial infections may be associated with increases in C reactive protein concentration within the normal range and that variations in the C reactive protein concentration in turn may be associated with levels of cardiovascular risk factors and chronic coronary heart disease.

DESIGN:

Population based cross sectional study.

SETTING:

General practices in Merton, Sutton, and Wandsworth.

SUBJECTS:

A random sample of 388 men aged 50-69 years from general practice registers. 612 men were invited to attend and 413 attended, of whom 25 non-white men were excluded. The first 303 of the remaining 388 men had full risk factor profiles determined.

INTERVENTIONS:

Measurements of serum C reactive protein concentrations by in house enzyme linked immunosorbent assay (ELISA); other determinations by standard methods. Coronary heart disease was sought by the Rose angina questionnaire and Minnesota coded electrocardiograms.

MAIN OUTCOME MEASURES:

Serum C reactive protein concentrations, cardiovascular risk factor levels, and the presence of coronary heart disease.

RESULTS:

Increasing age, smoking, symptoms of chronic bronchitis, Helicobacter pylori and Chlamydia pneumoniae infections, and body mass index were all associated with raised concentrations of C reactive protein. C Reactive protein concentration was associated with raised serum fibrinogen, sialic acid, total cholesterol, triglyceride, glucose, and apolipoprotein B values. C Reactive protein concentration was negatively associated with high density lipoprotein cholesterol concentration. There was a weaker positive relation with low density lipoprotein cholesterol concentration and no relation with apolipoprotein A I value. C Reactive protein concentration was also strongly associated with coronary heart disease.

CONCLUSION:

The body's response to inflammation may play an important part in influencing the progression of atherosclerosis. The association of C reactive protein concentration with coronary heart disease needs testing in prospective studies.

Comment in

PMID:
8616412
[PubMed - indexed for MEDLINE]
PMCID:
PMC2350910
Free PMC Article
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