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Nature. 1996 May 9;381(6578):127-51.

Crystal structure of a yeast TFIIA/TBP/DNA complex.

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  • 1Institut für Molekularbiologie und Biophysik, ETH-Hönggerberg, Zürich, Switzerland.


The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.

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