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1: Fukushima J Med Sci. 1995 Jun;41(1):43-9.Links

A case of autoimmune hemolytic anemia induced by IFN-beta therapy for type-C chronic hepatitis.

Kazuta Y, Watanabe N, Sagawa K, Kobayashi H, Kojima T, Funabashi H, Moritoh T, Kasukawa R.

Department of Internal Medicine, Hanawa Kohsei Hospital, Fukushima, Japan.

A 51-year old woman who had type-C chronic hepatitis developed autoimmune hemolytic anemia after 4 weeks treatment with a total 48 million interferon-beta, 6 million 8 times. Indirect Coomb's test turned from negative to positive through IFN therapy and a complication of asymptomatic primary biliary cirrhosis was confirmed by histologic findings of the biopsied liver which was performed during IFN therapy and a presence of anti-mitochondrial antibody. After stopping IFN therapy and adding prednisolone anemia improved in getting negative indirect Coombs test but remaining positive direct Coombs test.

PMID: 8606041 [PubMed - indexed for MEDLINE]

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