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Nat Struct Biol. 1996 Mar;3(3):259-66.

Crystal structure of the macrophage migration inhibitory factor from rat liver.

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  • 1Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan.

Abstract

The tertiary structure of the macrophage migration inhibitory factor (MIF) from rat liver (12,300 Mr) is presented at 2.2 A resolution. Each monomer consists of two beta/alpha/beta motifs aligned in quasi two-fold symmetry, comprising a domain consisting of a four-stranded mixed beta-sheet and two antiparallel alpha-helices. The protein exists as a trimer in the crystal. An extra beta-strand that is almost perpendicular to the other beta-strands joins to the beta-sheet of the neighbouring monomer in the trimer. Unexpected similarities were detected between MIF and two kinds of isomerase.

PMID:
8605628
[PubMed - indexed for MEDLINE]
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