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Dev Med Child Neurol. 1996 Feb;38(2):166-70.

Congenital bilateral perisylvian syndrome in a monozygotic twin with intra-uterine death of the co-twin.

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  • 1Department of Neurology (Pediatric Neurology), Hopital Erasme, Universite Libre de Bruxelles, Belgium.


Congenital bilateral perisylvian syndrome was diagnosed in a two-year- old boy with signs of pseudobulbar and diplegic cerebral palsy presenting on MRI a polymicrogyric appearance of the perisylvian regions. He was born from a monochorionic bi-amniotic twin pregnancy complicated by twin-twin transfusion syndrome and death of the co-twin between the 16th and 18th weeks of gestation. Ventricular enlargement and hepatic hyperechogenic lesions were seen during his sonographic intra-uterine follow-up. The authors suggest that ischaemic injury occurred in this patient as a consequence of acute haemodynamic changes induced by the death of his co-twin.

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