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Science. 1996 Apr 19;272(5260):408-11.

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.

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  • 1Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.

Abstract

Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo and causes mammalian cells to arrest in the cell cycle. A trapoxin affinity matrix was used to isolate two nuclear proteins that copurified with histone deacetylase activity. Both proteins were identified by peptide microsequencing, and a complementary DNA encoding the histone deacetylase catalytic subunit (HD1) was cloned from a human Jurkat T cell library. As the predicted protein is very similar to the yeast transcriptional regulator Rpd3p, these results support a role for histone deacetylase as a key regulator of eukaryotic transcription.

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PMID:
8602529
[PubMed - indexed for MEDLINE]
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