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    Science. 1996 Apr 19;272(5260):408-11.

    A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.

    Taunton J, Hassig CA, Schreiber SL.

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    Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.

    Abstract

    Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo and causes mammalian cells to arrest in the cell cycle. A trapoxin affinity matrix was used to isolate two nuclear proteins that copurified with histone deacetylase activity. Both proteins were identified by peptide microsequencing, and a complementary DNA encoding the histone deacetylase catalytic subunit (HD1) was cloned from a human Jurkat T cell library. As the predicted protein is very similar to the yeast transcriptional regulator Rpd3p, these results support a role for histone deacetylase as a key regulator of eukaryotic transcription.

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    PMID:
    8602529
    [PubMed - indexed for MEDLINE]

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