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    Science. 1996 Apr 5;272(5258):74-9.

    Population dynamics of immune responses to persistent viruses.

    Source

    Department of Zoology, University of Oxford, UK.

    Abstract

    Mathematical models, which are based on a firm understanding of biological interactions, can provide nonintuitive insights into the dynamics of host responses to infectious agents and can suggest new avenues for experimentation. Here, a simple mathematical approach is developed to explore the relation between antiviral immune responses, virus load, and virus diversity. The model results are compared to data on cytotoxic T cell responses and viral diversity in infections with the human T cell leukemia virus (HTLV-1) and the human immunodeficiency virus (HIV-1).

    PMID:
    8600540
    [PubMed - indexed for MEDLINE]

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