Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 1996 Apr 5;272(5258):67-74.

Population biology of antigen presentation by MHC class I molecules.

Author information

  • 1Department of Structural Biology, Stanford University, CA 94305 USA.

Abstract

In principle, the function of major histocompatibility complex (MHC) molecules is simple: to bind a peptide and engage a T cell. In practice, placing this function within the context of the immune response begs questions of population biology; How does the immune response emerge from the interactions among populations of peptides, T cells and MHC molecules? Within a population of vertebrates, how does MHC polymorphism stamp individuality on the response? Does polymorphism confer differential advantages in responding to parasites? How are the pressures on the MHC reflected in turnover of alleles? The role of mutation, recombination, selection, and drift in the generation and maintenance of MHC class 1 polymorphism are considered.

Comment in

  • Peopling the Americas. [Science. 1996]
PMID:
8600539
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk