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1: Ann Emerg Med. 1996 Mar;27(3):382-5.Click here to read Links

Atypical presentation of 4-aminopyridine overdose.

Pickett TA, Enns R.

Department of Emergency Medicine, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada.

4-Aminopyridine (4-AP) is an investigational drug for the treatment of neurologic disorders including multiple sclerosis (MS). Until recently, relatively little was known about 4-AP toxicity in overdose; the only recorded cases involved neurologic symptoms ranging from mild parasthesias to tonic-clonic seizures. We report a case of accidental 4-AP overdose that resulted in continuous, dystonic, choreoathetoid-type movements that responded to treatment with standard anticonvulsant dosages of benzodiazepines.

PMID: 8599505 [PubMed - indexed for MEDLINE]