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Lancet. 1979 Apr 7;1(8119):752-5.

Dietary cholesterol is co-carcinogenic for human colon cancer.


Colorectal carcinoma is becoming the most common form of visceral cancer in Western populations. A fat-related dietary factor is implicated in its pathogenesis, and evidence in man suggests that this factor may be cholesterol. Dietary cholesterol is co-carcinogenic in animals with colon cancer, and there is indirect evidence for a similar role in man. It is proposed that prolonged exposure to dietary cholesterol is co-carcinogenic for human colon cancer in that it facilitates the development, growth, and spread of this disease.

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