Abstract
The contractile action of bradykinin on isolated smooth muscles is known to be potentiated by special peptides isolated from snake venoms and other animal sources. A fraction F (AppF) has been derived from Agkistrodon piscivorus piscivorus venom. This fraction does not increase the depressor effect of bradykinin n blood pressure, potentiates the action of bradykinin on isolated guinea-pig ileum and prolongs the duration of relaxation in isolated rat duodenum. This fraction was able to inhibit the conversion of angiotensin I to angiotensin II in vitro. The primary structure of this decapeptide is given.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiotensin I / metabolism
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Angiotensin II / metabolism
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Angiotensin-Converting Enzyme Inhibitors / pharmacology
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Animals
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Blood Pressure / drug effects*
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Bradykinin / metabolism
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Bradykinin / pharmacology
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Crotalid Venoms / chemistry*
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Drug Synergism
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Guinea Pigs
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Mass Spectrometry
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Muscle, Smooth / drug effects*
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Oligopeptides / chemistry
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Oligopeptides / isolation & purification
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Oligopeptides / pharmacology*
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Peptide Fragments / chemistry
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Peptide Fragments / isolation & purification
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Peptide Fragments / pharmacology*
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Rats
Substances
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Angiotensin-Converting Enzyme Inhibitors
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Crotalid Venoms
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Oligopeptides
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Peptide Fragments
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bradykinin potentiating factors
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Angiotensin II
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Angiotensin I
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Bradykinin