Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nature. 1996 Mar 7;380(6569):41-6.

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor.

Author information

  • 1Pharma Division, F. Hoffmann-La Roche, Basle, Switzerland.

Abstract

Blood coagulation is initiated when tissue factor binds to coagulation factor VIIa to give an enzymatically active complex which then activates factors IX and X, leading to thrombin generation and clot formation. We have determined the crystal structure at 2.0-A degrees resolution of active-site-inhibited factor VIIa complexed with the cleaved extracellular domain of tissue factor. In the complex, factor VIIa adopts an extended conformation. This structure provides a basis for understanding many molecular aspects of the initiation of coagulation.

Comment in

PMID:
8598903
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk