Sterilisation of Babesia canis infections by imidocarb alone or in combination with diminazene

B L Penzhorn; B D Lewis; D T de Waal; L M López Rebollar

Sterilisation of Babesia canis infections by imidocarb alone or in combination with diminazene

J S Afr Vet Assoc. 1995 Sep;66(3):157-9.

Authors

B L Penzhorn¹, B D Lewis, D T de Waal, L M López Rebollar

Affiliation

¹ Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort.

PMID: 8596187

Abstract

Babesia canis infections were apparently sterilised by a single dose of imidocarb at 7.5 mg kg-1, as well as by a single dose of diminazene at 3.5 mg kg-1, followed by a single dose of imidocarb at 6 mg kg-1 the following day. This was confirmed by subinoculation of blood from these dogs to splenectomised recipients. Sterilisation of the infection is not recommended in endemic areas; a more rational approach would be to allow a state of premunity to develop in dogs at risk to repeated infections.

Publication types

Clinical Trial
Randomized Controlled Trial

MeSH terms

Animals
Antiprotozoal Agents / therapeutic use*
Babesiosis / drug therapy*
Babesiosis / immunology
Diminazene / therapeutic use*
Dog Diseases / drug therapy*
Dog Diseases / immunology
Dogs
Drug Therapy, Combination
Imidocarb / therapeutic use*
Immunity, Active / drug effects
Parasitemia / drug therapy*
Parasitemia / immunology
Trypanocidal Agents / therapeutic use*

Substances

Antiprotozoal Agents
Trypanocidal Agents
Imidocarb
Diminazene