The neurochemical and metabolic cascade following brain injury: moving from animal models to man.
Hovda DA,
Lee SM,
Smith ML,
Von Stuck S,
Bergsneider M,
Kelly D,
Shalmon E,
Martin N,
Caron M,
Mazziotta J, et al.
Department of Surgery, UCLA School of Medicine 90024, USA.
Experimental traumatic brain injury produces a series of cellular events contributing to a neurochemical and neurometabolic cascade. This cascade is defined by the release of neurotransmitters resulting in a massive ionic flux, which, consequently, produces an increase in glycolysis. This increase in glycolysis is followed by a metabolic diaschisis, which is related to the degree and extent of behavioral deficits. Clinical efforts have now determined that a similar cascade occurs in human head injury, validating the animal model as well as providing new assessment strategies for the management and treatment of brain injury.
PMID: 8594218 [PubMed - indexed for MEDLINE]