Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 1995 Nov;18(11):496-501.

The Rho's progress: a potential role during neuritogenesis for the Rho family of GTPases.

Author information

  • 1MRC Laboratory for Molecular Cell Biology, University College London, UK.

Abstract

Growth cones navigate by coupling extracellular guidance cues to directed outgrowth of the actin cytoskeleton through cyclical extension of filopodia and lamellipodia, but the biochemical basis of this coupling is at present unknown. Recent studies have shown that members of the Rho family of small GTPases regulate the formation of filopodia, lamellipodia and stress fibres in fibroblasts, and there are striking morphological similarities between spreading fibroblasts and advancing growth cones. This resemblance suggests that the Rho family of proteins could be the link between incoming signals and the regulation of both actin dynamics and cell-substratum adhesion in the neuronal growth cone.

PMID:
8592759
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk