Prog Brain Res. 1995;106:57-66.

The promoter of the human monoamine oxidase A gene.

Source

Department of Human Biological Chemistry and Genetics, Graduate School of Biomedical Sciences, University of Texas Medical Branch, Galveston 77555, USA.

Abstract

Monoamine oxidase (MAO) A (EC 1.4.3.4) oxidizes norepinephrine and serotonin and is expressed in a cell type-specific manner. Evidence that MAO A deficient males in a large Dutch kindred suffer from mild mental retardation and occasional episodes of impulsive-aggressive behavior makes it important to understand how the human MAO A promoter is regulated. Workers in multiple laboratories have isolated and characterized protein-coding sequences of the human MAO A gene and the DNA region where mRNA synthesis is initiated. After summarizing our published findings concerning where transcription of the human MAO A gene is initiated, I summarize representative results of transient expression assays aimed at assessing whether some potential gene regulatory agents affect the expression of luciferase from MAO A promoter reporter constructs when transfected into a mouse L cell line which expresses MAO A. These studies revealed no specific regulatory effects of serum, dexamethasone or a stable cyclic-AMP analogue on the human MAO A promoter introduced.

PMID:: 8584674; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Secondary Source ID, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Secondary Source ID

GENBANK/S81371

Grant Support

NS19543/NS/NINDS NIH HHS/United States

LinkOut - more resources

Molecular Biology Databases

DEXAMETHASONE - HSDB

Supplemental Content

Save items

Related citations in PubMed

A new look at the promoter of the human monoamine oxidase A gene: mapping transcription initiation sites and capacity to drive luciferase expression. [J Neurochem. 1994]
A new look at the promoter of the human monoamine oxidase A gene: mapping transcription initiation sites and capacity to drive luciferase expression.
Denney RM, Sharma A, Dave SK, Waguespack A. J Neurochem. 1994 Sep; 63(3):843-56.
Bidirectional promoter of human monoamine oxidase A (MAO A) controlled by transcription factor Sp1. [J Neurosci. 1994]
Bidirectional promoter of human monoamine oxidase A (MAO A) controlled by transcription factor Sp1.
Zhu QS, Chen K, Shih JC. J Neurosci. 1994 Dec; 14(12):7393-403.
Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation. [J Biol Chem. 2003]
Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation.
Wong WK, Chen K, Shih JC. J Biol Chem. 2003 Sep 19; 278(38):36227-35. Epub 2003 Jul 10.
Review Organization of MAO A and MAO B promoters and regulation of gene expression. [Neurotoxicology. 2004]
Review Organization of MAO A and MAO B promoters and regulation of gene expression.
Chen K. Neurotoxicology. 2004 Jan; 25(1-2):31-6.
Review Regulation of MAO-A and MAO-B gene expression. [Curr Med Chem. 2004]
Review Regulation of MAO-A and MAO-B gene expression.
Shih JC, Chen K. Curr Med Chem. 2004 Aug; 11(15):1995-2005.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.

Recent activity

Clear Turn Off Turn On

The promoter of the human monoamine oxidase A gene.
The promoter of the human monoamine oxidase A gene.
Prog Brain Res. 1995 ;106:57-66.

PubMed
Reptile-associated salmonellosis in New York State.
Reptile-associated salmonellosis in New York State.
Pediatr Infect Dis J. 1995 Nov ;14(11):955-9.

PubMed
The effect of fasting and fructose and glucose infusion on gluconeogenesis and t...
The effect of fasting and fructose and glucose infusion on gluconeogenesis and triose phosphate flux in rats in vivo.
Nutr Rev. 1995 Oct ;53(10):299-301.

PubMed
Central dysesthesia pain after traumatic spinal cord injury is dependent on N-me...
Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation.
Neurosurgery. 1995 Dec ;37(6):1080-7.

PubMed
Prolonged recovery and reduced adaptation in aged rat muscle following eccentric...
Prolonged recovery and reduced adaptation in aged rat muscle following eccentric exercise.
Mech Ageing Dev. 1995 Sep 15 ;83(3):185-200.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: