Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neuroreport. 1995 Oct 23;6(15):1985-8.

Two actin binding proteins, actin depolymerizing factor and cofilin, are associated with Hirano bodies.

Author information

  • 1Laboratory of Molecular Biology, MRC Centre, Cambridge, UK.

Abstract

Hirano bodies are intracellular, paracrystalline, rod-like structures which contain actin, tropomyosin, vinculin, alpha-actinin, amyloid beta-protein precursor and several microtubule associated proteins (MAPs). These bodies are observed more frequently in the elderly and in a number of neurodegenerative diseases including Alzheimer's disease. Many of the proteins known to be associated with Hirano bodies are actin binding proteins. We present immunohistological evidence that actin depolymerizing factor (ADF) and cofilin, two closely related proteins that bind and sever actin filaments, are also components of Hirano bodies. However, we could detect no difference in the levels of expression of either ADF or cofilin in the hippocampal tissue from normal individuals and Alzheimer's disease patients.

PMID:
8580423
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk