Trends Biochem Sci. 1995 Nov;20(11):470-5.

Recognition and specificity in protein tyrosine kinase-mediated signalling.

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Division of Signal Transduction, Beth Israel Hospital, Boston, MA 02115, USA.

Abstract

There are several factors that contribute to the specificities of protein tyrosine kinases (PTKs) in signal transduction pathways. While protein-protein interaction domains, such as the Src homology (SH2 and SH3) domains, regulate the cellular localization of PTKs and their substrates, the specificities of PTKs are ultimately determined by their catalytic domains. The use of peptide libraries has revealed the substrate specificities of SH2 domains and PTK catalytic domains, and has suggested cross-talk between these domains.

PMID:: 8578591; [PubMed - indexed for MEDLINE]

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R01 GM056203/GM/NIGMS NIH HHS/United States

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