Human gastric inhibitory polypeptide receptor: clo...[Genomics. 1995]

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1: Genomics. 1995 Oct 10;29(3):773-6. Links

Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA.

Yamada Y, Hayami T, Nakamura K, Kaisaki PJ, Someya Y, Wang CZ, Seino S, Seino Y.

Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Japan.

Gastric inhibitory polypeptide (GIP), which is released from the gastrointestinal tract, stimulates insulin secretion from pancreatic beta cells and plays a crucial role in the regulation of insulin secretion during the postprandial phase. We have isolated the human gene (GIPR) and cDNA encoding the GIP receptor by a combination of the conventional screening and polymerase chain reaction procedures. Human GIP receptor cDNA encodes a protein of 466 amino acids that is 81.5 and 81.2% identical to the previously cloned hamster and rat GIP receptor, respectively. Hydropathic analysis shows the presence of a signal peptide and seven potential transmembrane domains, a feature characteristic of the VIP/glucagon/secretin receptor family of G protein-coupled receptors. The human GIPR gene is about 13.8 kb long, consists of 14 exons, and carries 17 Alu repeats.

PMID: 8575774 [PubMed - indexed for MEDLINE]

Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma. [FEBS Lett. 1995]
Review[Gastric inhibitory polypeptide (GIP) and GIP receptor (GIPR)] [Nippon Rinsho. 1996]
Hamster gastric inhibitory polypeptide receptor expressed in pancreatic islets and clonal insulin-secreting cells: its structure and functional properties. [Biochem Biophys Res Commun. 1994]
Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor. [Diabetes. 1995]
ReviewPACAP/VIP receptors in pancreatic beta-cells: their roles in insulin secretion. [Ann N Y Acad Sci. 1996]

Patient Drug Information

Glucagon (GlucaGen Diagnostic Kit®) Glucagon is a hormone produced in the pancreas. Glucagon is used to raise very low blood sugar. Glucagon is also used in diagnostic testing of the stomach and other digestive organs.

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Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA.

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