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Toxicology. 1977 Apr;7(2):169-77.

Biological fate of 32P malathion in Gallus domesticus (desi poultry birds).


During this study, a minor surgical technique was developed for the separation of urine and faeces in birds and fate of 32P malathion was studied, following a single oral dose of 394 mg/kg. The birds showed characteristic signs and symptoms of organophosphorus poisoning and the results suggested that the compound is rapidly absorbed from the gastro-intestinal tract, significant quantities being detected in plasma after 0.5 h of ingestion. Highest concentration of 32P was present during 6 to 8 h of administration. At 6 h, 32P was highest in liver followed by other organs. With the lapse of time the concentration of 32P in various organs decreased at 48 h, it was not detected except in liver, kidney, lung and spleen when only traces were observed. The cumulative urinary and faecal excretion study revealed that within 24 h 90% is rapidly excreted mainly via the urine and only small amounts in the faeces. Metabolism studies showed that the compound is quickly metabolised. Because of the rapid turnover of the compound, this study indicated that the accumulation of this compound is unlikely in the body system.

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