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Arch Intern Med. 1996 Feb 12;156(3):337-9.

Rhinocerebral mucormycosis. Therapy with amphotericin B lipid complex.

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  • 1University of Arizona, College of Medicine, USA.


Rhinocerebral mucormycosis with intracranial involvement has a high mortality. The standard therapy consists of aggressive surgical d├ębridement accompanied by high doses of amphotericin B deoxycholate. Even with this therapy, the mortality rate has been 48% in the series reported since 1980. We treated a 60-year-old diabetic woman with rhinocerebral mucormycosis involving the cavernous sinus whose infection responded to medical therapy with amphotericin B lipid complex. To our knowledge, this is the only well-documented medical cure of a patient with rhinocerebral mucormycosis and intracranial involvement.

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