Abstract
Tetracyclines are widely used in medical and dental practice. Since these drugs chelate calcium salts they are incorporated into bones and teeth during calcification. A review of the literature on the pharmacology of these drugs, their incorporation into calcified tissues and the management of tetracycline-stained teeth is given.
MeSH terms
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Anti-Bacterial Agents / pharmacokinetics
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Anti-Bacterial Agents / pharmacology*
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Bone and Bones / drug effects*
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Bone and Bones / metabolism
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Calcification, Physiologic / drug effects
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Calcium / pharmacokinetics
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Chelating Agents / pharmacokinetics
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Chelating Agents / pharmacology
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Humans
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Tetracyclines
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Tooth / drug effects*
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Tooth / metabolism
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Tooth Discoloration / chemically induced
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Tooth Discoloration / therapy
Substances
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Anti-Bacterial Agents
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Chelating Agents
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Tetracyclines
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Calcium