Concurrent oral poliovirus and rhesus-human reassortant rotavirus vaccination: effects on immune responses to both vaccines and on efficacy of rotavirus vaccines. The US Rotavirus Vaccine Efficacy Group

M B Rennels; R L Ward; M E Mack; E T Zito

doi:10.1093/infdis/173.2.306

Concurrent oral poliovirus and rhesus-human reassortant rotavirus vaccination: effects on immune responses to both vaccines and on efficacy of rotavirus vaccines. The US Rotavirus Vaccine Efficacy Group

J Infect Dis. 1996 Feb;173(2):306-13. doi: 10.1093/infdis/173.2.306.

Authors

M B Rennels¹, R L Ward, M E Mack, E T Zito

Affiliation

¹ Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, USA.

PMID: 8568290
DOI: 10.1093/infdis/173.2.306

Abstract

Interference between oral poliovirus vaccine (OPV) and monovalent (RRV-S1) and tetravalent (RRV-TV) rhesus-human rotavirus vaccines was evaluated. Serum antibody responses to OPV and rotavirus vaccines and efficacy of rotavirus vaccines were compared among control and vaccine groups stratified by number of concurrent OPV and rotavirus vaccinations received. Neutralizing antibody titers to poliovirus type 1 tended to rise more steeply in placebo than RRV-TV recipients, but there were no significant differences in seroprevalence or in geometric mean titers (GMTs) of antibodies to types 1, 2, or 3 among groups. Concurrent OPV resulted in lower IgA GMTs to rotavirus in RRV-S1 but not RRV-TV recipients. Rotavirus gastroenteritis rates among rotavirus vaccines did not differ by number of concurrent OPV doses received, but the sample sizes were too small to rule out any effect. These results suggest OPV and rhesus-human rotavirus vaccines may be given at the same visit in the United States.

Publication types

Clinical Trial
Comparative Study
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Oral
Antibodies, Viral / biosynthesis*
Child, Preschool
Double-Blind Method
Gastroenteritis / immunology
Gastroenteritis / prevention & control
Gastroenteritis / virology
Humans
Infant
Poliomyelitis / immunology
Poliomyelitis / prevention & control
Poliovirus / immunology
Poliovirus Vaccine, Oral / administration & dosage*
Poliovirus Vaccine, Oral / adverse effects
Poliovirus Vaccine, Oral / immunology
Retrospective Studies
Rotavirus / immunology
Rotavirus Infections / immunology
Rotavirus Infections / prevention & control*
Rotavirus Vaccines*
Vaccination*
Vaccines, Attenuated / administration & dosage
Vaccines, Combined
Viral Vaccines / administration & dosage*
Viral Vaccines / adverse effects
Viral Vaccines / immunology

Substances

Antibodies, Viral
Poliovirus Vaccine, Oral
Rotavirus Vaccines
Vaccines, Attenuated
Vaccines, Combined
Viral Vaccines
rhesus rotavirus vaccine