Cell. 1996 Jan 26;84(2):321-30.

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.

Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR.

Source

Department of Pathology and Laboratory Medicine, St. Jude Children's Research Hospital Memphis, Tennessee 38105, USA.

Abstract

The AML1-CBF beta transcription factor is the most frequent target of chromosomal rearrangements in human leukemia. To investigate its normal function, we generated mice lacking AML1. Embryos with homozygous mutations in AML1 showed normal morphogenesis and yolk sac-derived erythropoiesis, but lacked fetal liver hematopoiesis and died around E12.5. Sequentially targeted AML1-/-es cell retained their capacity to differentiate into primitive erythroid cells in vitro; however, no myeloid or erythroid progenitors of definitive hematopoietic origin were detected in either the yolk sac or fetal livers of mutant embryos. Moreover, this hematopoietic defect was intrinsic to the stem cells in that AML1-/-ES cells failed to contribute to hematopoiesis in chimeric animals. These results suggest that AML1-regulated target genes are essential for definitive hematopoiesis of all lineages.

PMID:: 8565077; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Molecular Biology Databases

KOMP Repository

Miscellaneous

Supplemental Content

Save items

Related citations in PubMed

Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors. [Blood. 1998]
Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.
Okuda T, Cai Z, Yang S, Lenny N, Lyu CJ, van Deursen JM, Harada H, Downing JR. Blood. 1998 May 1; 91(9):3134-43.
Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor. [Proc Natl Acad Sci U S A. 1997]
Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor.
Niki M, Okada H, Takano H, Kuno J, Tani K, Hibino H, Asano S, Ito Y, Satake M, Noda T. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5697-702.
Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos. [Blood. 2005]
Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos.
Maki K, Yamagata T, Asai T, Yamazaki I, Oda H, Hirai H, Mitani K. Blood. 2005 Sep 15; 106(6):2147-55. Epub 2005 May 24.
Review Core-binding factor: a central player in hematopoiesis and leukemia. [Cancer Res. 1999]
Review Core-binding factor: a central player in hematopoiesis and leukemia.
Speck NA, Stacy T, Wang Q, North T, Gu TL, Miller J, Binder M, Marín-Padilla M. Cancer Res. 1999 Apr 1; 59(7 Suppl):1789s-1793s.
Review The AML1 gene: a transcription factor involved in the pathogenesis of myeloid and lymphoid leukemias. [Haematologica. 1997]
Review The AML1 gene: a transcription factor involved in the pathogenesis of myeloid and lymphoid leukemias.
Lo Coco F, Pisegna S, Diverio D. Haematologica. 1997 May-Jun; 82(3):364-70.

See reviews... See all...

Cited by over 100 PubMed Central articles

Factors regulating microglia activation. [Front Cell Neurosci. 2013]
Factors regulating microglia activation.
Kierdorf K, Prinz M. Front Cell Neurosci. 2013; 7:44. Epub 2013 Apr 23.
Runt-related transcription factor 2 (RUNX2) inhibits p53-dependent apoptosis through the collaboration with HDAC6 in response to DNA damage. [Cell Death Dis. 2013]
Runt-related transcription factor 2 (RUNX2) inhibits p53-dependent apoptosis through the collaboration with HDAC6 in response to DNA damage.
Ozaki T, Wu D, Sugimoto H, Nagase H, Nakagawara A. Cell Death Dis. 2013 Apr 25; 4:e610. Epub 2013 Apr 25.
Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21. [J Biomed Res. 2010]
Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21.
Ruparelia A, Wiseman F, Sheppard O, Tybulewicz VL, Fisher EM. J Biomed Res. 2010 Mar; 24(2):87-99.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

AML1, the target of multiple chromosomal translocations in human leukemia, is es...
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.
Cell. 1996 Jan 26 ;84(2):321-30.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: