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C R Seances Soc Biol Fil. 1995;189(4):637-41.

[Epidermal growth factor (EGF) can induce prostatic buds in the absence of androgens].

[Article in French]

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  • 1Département de Biologie, Faculté des Sciences pharmaceutiques, Teikyo Université, Kanagawa-Ken, Japan.


We have investigated the prostatic bud induction in the urogenital sinus of fetal rats and mice when the sinuses were cultured with non-androgenic growth factors, and found that epidermal growth factor (EGF) as well as transforming growth factor-alpha (TGF-alpha) powerfully induces the prostatic buds in the absence of androgens even in the androgen-receptor-deficient Tfm sinuses. Immunofluorescence study revealed that endogenous EGF and EGF receptor exist in the sinus mesenchyme of 19.5-day fetal male rats, where many prostatic buds are appearing.

[PubMed - indexed for MEDLINE]
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