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Trends Microbiol. 1995 Oct;3(10):401-4.

Prospects for new vaccines against tuberculosis.

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  • Dept of Microbiology, Colorado State University, Fort Collins 80523, USA.

Abstract

The spectacular failure of the existing bacille Calmette-Guérin (BCG) vaccine in recent tuberculosis-control trials has prompted a search for potential replacements. Imaginative approaches currently under development include the modulation of BCG by the production of auxotrophic mutants or cytokine-secreting recombinants, and the development of subunit vaccines based on the major proteins of Mycobacterium tuberculosis.

PMID:
8564360
[PubMed - indexed for MEDLINE]
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