Nat Genet. 1996 Feb;12(2):159-67.

The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9.

Borrow J, Shearman AM, Stanton VP Jr, Becher R, Collins T, Williams AJ, Dubé I, Katz F, Kwong YL, Morris C, Ohyashiki K, Toyama K, Rowley J, Housman DE.

Source

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA.

Abstract

The t(7;11)(p15;p15) translocation is a recurrent chromosomal abnormality associated primarily with acute myeloid leukaemia (FAB M2 and M4). We present here the molecular definition of this translocation. On chromosome 7 positional cloning revealed the consistent rearrangement of the HOXA9 gene, which encodes a class I homeodomain protein potentially involved in myeloid differentiation. On chromosome 11 the translocation targets the human homologue of NUP98, a member of the GLFG nucleoporin family. Chimaeric messages spliced over the breakpoint fuse the GLFG repeat domains of NUP98 in-frame to the HOXA9 homeobox. The predicted NUP98-HOXA9 fusion protein may promote leukaemogenesis through inhibition of HOXA9-mediated terminal differentiation and/or aberrant nucleocytoplasmic transport.

Comment in

The malevolence of matchmaking. [Nat Genet. 1996]
The malevolence of matchmaking.Barr FG. Nat Genet. 1996 Feb; 12(2):113-4.

PMID:: 8563754; [PubMed - indexed for MEDLINE]

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Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. [Nat Genet. 1996]
Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia.
Nakamura T, Largaespada DA, Lee MP, Johnson LA, Ohyashiki K, Toyama K, Chen SJ, Willman CL, Chen IM, Feinberg AP, et al. Nat Genet. 1996 Feb; 12(2):154-8.
The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9. [Genes Chromosomes Cancer. 2002]
The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9.
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Panagopoulos I, Isaksson M, Billström R, Strömbeck B, Mitelman F, Johansson B. Genes Chromosomes Cancer. 2003 Jan; 36(1):107-12.
Review NUP98 fusion in human leukemia: dysregulation of the nuclear pore and homeodomain proteins. [Int J Hematol. 2005]
Review NUP98 fusion in human leukemia: dysregulation of the nuclear pore and homeodomain proteins.
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The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes fo...
The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9.
Nat Genet. 1996 Feb ;12(2):159-67.

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