Arch Neurol. 1977 May;34(5):313.

Pheniramine aminosalicylate overdosage. Reversal of delirium and choreiform movements with tacrine treatment.

Abstract

We describe a case of central anticholinergic syndrome with choreiform movements after an overdose of pheniramine aminosalicylate. The symptoms and signs of the condition were reversed by the intravenous administration of the cholinesterase-inhibitor tetrahydroaminacrine. We also discuss the concept of adrenergic-cholinergic imbalance in relation to this case and recommend the use of centrally acting anticholinesterase agents in the treatment of specific cases of drug overdose.

PMID:: 856127; [PubMed - indexed for MEDLINE]

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