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    Mech Dev. 1995 Sep;53(1):87-96.

    A single homeodomain binding site restricts spatial expression of Wnt-1 in the developing brain.

    Iler N, Rowitch DH, Echelard Y, McMahon AP, Abate-Shen C.

    Source

    Center for Advanced Biotechnology and Medicine, Piscataway, NJ 08854, USA.

    Abstract

    In this study we investigate the molecular mechanisms that are responsible for the restricted expression of Wnt-1 during embryogenesis. We report that a single homeodomain binding site, HBS1, within the Wnt-1 enhancer contributes to appropriate spatial expression of Wnt-1 in the developing nervous system. This HBS1 site may be required for repressing Wnt-1 expression in the developing forebrain since specific mutations of this site result in an extension of the rostral boundary of Wnt-1/lacZ staining in transgenic embryos. We further demonstrate that a subset of homeodomain proteins expressed in the forebrain (i.e., Dix2, Emx2) interact specifically with HBS1. These findings suggest that these (or related) homeodomain proteins may regulate expression of Wnt-1 during normal brain development by interacting with the HBS1 site in the Wnt-1 enhancer.

    PMID:
    8555114
    [PubMed - indexed for MEDLINE]

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