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Am J Ophthalmol. 1995 Dec;120(6):757-66.

A twin study of age-related macular degeneration.

Author information

  • 1Division of Ophthalmology, Cleveland Clinic Foundation, OH 44195, USA.

Abstract

PURPOSE:

To determine the importance of genetic factors in age-related macular degeneration by using a twin study to compare the concordance of age-related macular degeneration in monozygotic and dizygotic twin pairs.

METHODS:

We prospectively examined 134 consecutive twin pairs and two triplet sets for age-related macular degeneration. The zygosity was determined by genetic laboratory tests.

RESULTS:

The concordance of age-related macular degeneration was 100% (25 of 25) in monozygotic and 42% (five of 12) in dizygotic twin pairs. The other twins or triplets had no macular changes of age-related macular degeneration.

CONCLUSIONS:

The statistically significant higher concordance of age-related macular degeneration in monozygotic than in dizygotic twin pairs and the clinical heterogeneity of age-related macular degeneration strongly suggest the importance of genetic and nongenetic factors, respectively, in age-related macular degeneration.

PMID:
8540549
[PubMed - indexed for MEDLINE]
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