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    Am J Ophthalmol. 1995 Dec;120(6):757-66.

    A twin study of age-related macular degeneration.

    Meyers SM, Greene T, Gutman FA.

    Source

    Division of Ophthalmology, Cleveland Clinic Foundation, OH 44195, USA.

    Abstract

    PURPOSE:

    To determine the importance of genetic factors in age-related macular degeneration by using a twin study to compare the concordance of age-related macular degeneration in monozygotic and dizygotic twin pairs.

    METHODS:

    We prospectively examined 134 consecutive twin pairs and two triplet sets for age-related macular degeneration. The zygosity was determined by genetic laboratory tests.

    RESULTS:

    The concordance of age-related macular degeneration was 100% (25 of 25) in monozygotic and 42% (five of 12) in dizygotic twin pairs. The other twins or triplets had no macular changes of age-related macular degeneration.

    CONCLUSIONS:

    The statistically significant higher concordance of age-related macular degeneration in monozygotic than in dizygotic twin pairs and the clinical heterogeneity of age-related macular degeneration strongly suggest the importance of genetic and nongenetic factors, respectively, in age-related macular degeneration.

    PMID:
    8540549
    [PubMed - indexed for MEDLINE]

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