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Endocrinology. 1996 Jan;137(1):375-8.

Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas.

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  • 1Department of Physiology and Internal Medicine, Ohio State University, Columbus 43210, USA.


The ret/PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be restricted to human papillary thyroid carcinomas. This report shows that transgenic mice with thyroid-targeted expression of the ret/PTC1 oncogene developed thyroid carcinomas with considerable similarities to human papillary thyroid carcinomas, particularly in the nuclear cytologic features and the presence of local invasion. Our findings indicate that ret/PTC2 is not only a biomarker associated with papillary thyroid carcinomas, but is also the only proven specific genetic event leading to the development of papillary thyroid carcinoma.

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